Liver function tests - Free Essay Example

Sample details Pages: 9 Words: 2563 Downloads: 6 Date added: 2017/06/26 Category Health Essay Type Essay any type Did you like this example? Introduction The liver is the largest internal organ in the body. In adult the liver weighs approximately 1-2.5 kilograms. It is â€Å"wedge-shaped†, soft and reddish-brown in colour. Don’t waste time! Our writers will create an original "Liver function tests" essay for you Create order It is situated underneath the diaphragm. The liver is divided into right and left lobes by the middle hepatic vein. The right lobe is bigger and consists of caudate and quadrate lobes. The blood is supplied to the liver constitute 25% of the resting cardiac output and through two major blood vessels: hepatic artery and portal vein. Blood leaves the liver via the hepatic vein, which drains directly into the inferior vena cava. Bile is formed in the liver and it is collected in the bile capillaries which drain into the right and left hepatic ducts. The liver is organised in lobules within which blood flows past hepatic cells via sinusoids from branches of the portal vein (bringing absorbed materials from gastrointestinal tract) to the central vein of each lobule. Hepatic artery blood (providing oxygen needed for many of the metabolic processes carried out by the liver) also enters the sinusoids. The central veins coalesce to form the hepatic veins which drain into the inferior vena cava. Each liver cell is also apposed to several bile canaliculi. The canaliculi coalesce to form the right and left hepatic ducts, which join outside the liver to form the common hepatic duct. The cystic duct drains the gallbladder. The hepatic duct unites with the cystic duct to form the common bile duct. The common bile duct enters the duodenum at the papilla. Ganong, (1995) Hepatocytes or parenchymal (liver cells) which further classified on the basis of their site in the lobule comprise about 60% kupffer cells lining the hepatic sinusoids comprise 30% of the liver cells and the remaining 10% of cells consist of vascular and supporting tissue and bile ducts. The significant important of the liver came from the ability of this organ to perform a wide variety of functions which contribute in the body homeostasis, in particular regulation of blood sugar. When there is an excess sugar, the pancreatic cells secret the hormone insulin that converts excess sugar into glycogen (st orage form of glucose). Glycogen provide rapid accessible source of energy for the body when blood glucose decrease. Also gluconeogenesis (formation of new glucose) from amino acids such as alanine and ascorbic acid take place in liver. The coagulation factors which are required for blood clotting, albumin and various lipoproteins which are required for transport of lipid in blood stream are synthesized in the liver. The only exception of protein synthesis is the synthesis of immunoglobulin. Cholesterol which serves as precursor of steroid hormones is mostly synthesized in by the liver. Also liver has the ability to excrete and detoxify e.g. ammonia formed from the breakdown of amino acids or microbial action in the gastrointestinal tract converted to urea. Steroid hormones which are inactivated by conjugation with glucuronate and sulphate excreted into urine as water soluble forms. A wide range of medications (drugs) inactivated by endoplasmic reticulum enzymes and some are excr eted in the bile. Kupffer cells in the hepatic sinusoid extract toxins absorbed from the gastrointestinal tract. Other important excretory function is the excretion of bile acid formed from cholesterol in the liver to gall bladder where it stored until required for lipid digestion in the small intestine. The ability of liver to carry out its excretory function of the metabolism end products depends on, healthy functioning hepatocytes, adequate blood flow through the liver and patent biliary duct. The other important function of liver is Storage of vitamins such as vitamin A, D and vitamin B12. In addition, metabolism and excretion of bilirubin is one of the major functions of the liver. Bilirubin is an ecteric waste product pigment formed from the breakdown of haemoglobin (Hb) in the red blood cells in the lymph reticular system at the end of their life span which is approximately 120 days. Normally an adult produces about 450 umol/L daily. Gaw et al, (1999). Hb contains four hae m group, an iron atom and prophyrin ring attached to each haem group. When Hb molecules metabolize, the iron atoms are removed and reused again in the processing of a new Hb molecule. The prophyrin ring breaks to form a open tetrapyrole derivative biliverdin chain which is further reduced to form unconjugated bilirubin (lipid soluble).Whitby, (1988). The lipid-soluble bilirubin can cross cell membrane include brain barrier and cause brain cell damage. Therefore it has to be transported by a special carrier called albumin in the plasma in order to be converted to water-soluble so that can be excreted into bile. The binding of albumin accomplished by being not enter cells readily and also not filtered through glumerulus unless there is glomerular proteinuria. When the albumin-bilirubin complex reach the liver, it dissociates by the receptors on the plasma at the same time. Inside hepatocytes, bilirubin molecules join to relatively non-specific anion binding proteins called ligandin (Y protein), is soluble transport protein in the smooth endoplasmic reticulum. Calbreath, (1992). The glucuronic acid molecules attach to unconjugated bilirubin molecules to form bilirubin glucuronides in a reaction mediated by uridine diphosphate (UDP). Bilirubin glucuronides complex is water-soluble conjugated bilirubin which then excreted into small intestine. The conjugation process depends on the active secretion of bile acids and therefore serum bile acids concentration are more sensitive index of hepatic transport function than the total bilirubin. Small amount undergoes reabsorption in the small intestine and the rest is degraded by bacterial action mainly in the colon where it is de-conjugated to form urobilinogen. Portions of urobilinogen re-enter the hepatic circulation and excreted by the liver into bile. Small fraction filtered by kidney into urine, but the majority is excreted in faeces providing its orange-yellow characteristic. If the bilirary tract becomes block ed, serum bilirubin concentration will rise as uncojugated bilirubin not excreted and the patient becomes jaundice. Jaundice is a yellow discoloration of the skin or the sclera of the eye. The yellowish coloration is caused by an excess amount of bilirubin in the plasma which is not detectable until the concentration is greater than 40 umol/L. gaw, et al (1999). The normal concentration is up to 20 umol/L. causes of jaundice classified into three categories including haemolytic (prehepatic) jaundice characterized by an increased breakdown of haemoglobin, hepatic jaundice due to failure of the conjugation mechanism and post hepatic or obstructive jaundice because of obstruction of biliary system. Most newborn babies are characterized with physiological or neonatal jaundice due to natural process of breaking down RBCs. As their livers are immature, they can not process bilirubin as quickly as when they are old. This increase in bilirubin concentration and has no significance to do wit h liver. Marshal, (2000). In clinical practice usually all the tests related to liver diseases are called liver function tests (LFT). Biochemical tests include measurement of bilirubin, the aminotransferases (ALT and AST), albumin total protein and alkaline pkosphatase in serum specimen. Albumin and total protein reflect the synthetic liver function. ALT and AST used to measure the severity of liver cells damage although they are not specific index of acute damage to hepatocytes, but they are sensitve indicators to cytoplasmic and mitochondrial membrane. Gaw, et al (1999). Increased conjugation bilirubin concentration and increased ALP activity at sinusoidal surface indicate cholestasis, a blockage in the bile flow. Prolonged cholestasis can result in severe jaundice with very high bilirubin concentration result in deposition of bile salts, characterized by itching, bleeding due to vitamin K malabsorption, cholesterol retention and dark urine with pale stool. The prothrombin time (PT) which is used to asses the synthetic function of liver is prolonged due to cholestasis. Measurement of ? glutamyl transferase can give an indication of hepatocellular enzyme induction due to drugs or alcohol. Materials and method Please refer to medical biochemistry practical book (BMS2). Result Calculation Determination of ALP The equation obtained from the graph is used to calculate the amount of phenol liberated by the action of ALP. The equation is: Y = 0.1753 The enzyme activity is measured in international unit per 1 minute (IU/1) therefore to obtain the activity, the result has to be converted first to umol/1 and then divided by the incubation time (15 minutes) as follow: (Value of phenol concentration in mmol/1 X 1000) / 15 = IU/L Patient 1: Result: 0.207 / 0.1753 = 1.18083 x 1000   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  = 1180.8 umol/L To get the enzyme activity in 1 minute: = 1180.8 / 15 = 78.7 IU/L ALP enzyme activity of patient 1= 78.7 IU/L Patient 2: Result: 0.215 / 0.1753 = 1.2264 x 1000   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  = 1226.4 umol/L To get the enzyme act ivity in 1 minute: = 1226.4 / 15 = 81.7 IU/L ALP enzyme activity of patient 2 = 81.7 IU/L Determination of bilirubin The concentration of bilirubin is calculated by using the following equation Absorbance of the test x STD concentration Absorbance of STD Result: Patient 1 = (0.413/0.431) x 350 = 335.3 umol/L Patient 2 = (0.037/0.431) x 350 = 30 umol/L The results of Aspartate transaminase (AST), albumin and total protein were provided by the tutor. Conclusion The biochemical finding shows that patient 1 may have haemolytic disease where as the other patient (patient 2) suffer from acute hepatitis. Discussion Liver function test are done to asses the integrity of the liver to carry out its normal synthetic and metabolic functions. This is achieved through series of numerical tests that reflect the healthiness of the liver when comparing the result obtained with normal reference ranges. The measurements of enzyme activities are very useful in following the progress of the liver disease once the diagnosis has been made. From the result it is obvious that patient 1 ha s got normal TP, ALB, AST and ALP results, which means that there is liver damage. Total protein is combined of immunoglobulin proteins and other proteins. A persons total protein level gives information about the liver damage, kidney damage and nutritional health. Albumin is small protein made in the liver. If a person suffers from liver damage, the albumin concentration will drop because the liver can not maintain the normal production of albumin. Aspartate transminase (AST) is the enzyme found in the liver, heart and muscle. Levels of this enzyme are usually assessed in conjugation with reading for other liver enzyme to determine or monitor the liver involvement. On other hand the bilirubin is very high above the normal range (hyperbilirubiaemia) and normally the bilirubin which is present in plasma is unconjugated bilirubin. Since the unconjugated bilirubin is high it indicates that is excessive red blood cells (RBCs) destruction (haemolysis) which occurs in haemolytic anaemi a. Normally the red blood cells survival is 120 days, but in haemolytic anaemia is less. Because of that the RBCs are destroyed in large quantities in the RE system (particularly the spleen). When the RBCs are destroyed, the haemoglobin is released and bilirubin is produced. It is mainly produced from the haem moiety of the haemoglobin (it is also produced from myoglobin, cytochroms and peroxidase, which are widely distributed in the body). The liver can not conjugate and remove this large amount of unconjugated bilirubin and since it is protein bound the renal glomeruli can not filter it. That leads to overflow of unconjugated bilirubin in blood circulation. These mean that this patient may have haemolytic jaundice (prehepatic jaundice), because the protein synthesis is normal and ALP, AST are normal which means that there is no liver involvement. Haemolytic jaundice also occurs in haemolytic Disease of Newborn, transfusion of incompatible blood, hereditary spherocytosis and aut oimmune red cell destruction. Marshall,(2000). The results of patient 2 show normal total protein, albumin and ALP. There is a slight increase in bilirubin level (hyperbilirubinaemia) and AST is above the very high. AST is an intracellular enzyme and is mostly found in the cytoplasmic and mitochondrial membrane of hepatocytes. So it is a sensitive marker for the severity of damage hepatocytes. ALP concentration usually rises in cholestasis (this is by extra-hepatic obstruction of the bile duct) but in this patient was normal, which means that the kupffer cells and sinusoidal surface is not yet damaged. Total protein and albumin were also normal and that indicates that the metabolism and synthesis in the liver is not yet affected. Bilirubin was slightly high which support that there is liver disease and due to this, there is defect of bile salt and bile pigment excretion. In addition to that, conjugation and detoxification functions are well defected because of hepatic cells damag ed. These happen due to a condition called Hepatitis (liver inflammation). Hepatitis is the common cause of acute liver injury. Acute hepatitis usually occurs due to viral infection particularly with hepatitis viruses A, B, C, D and E, but also Epstein-bar virus and cytomegalovirus or toxin (e.g. alcohol and paracetamol). Marshall, (2000) In the early stages of hepatitis, increased plasma ALT and AST activities may be the only abnormal chemical finding. There will be also an increased level of urobilinogen and bilirubin in urine (the urine will be darkened). The stool may be very pale due to impaired biliary excretion of bilirubin and urobilinogen then disappears more or less completely from the urine. Marshall, (2000) The above results reveal that liver is functioning well but partly defected because of the early stage of the disease. This patient may have acute liver disease (Acute hepatitis). To confirm these results hepatitis virus profiles should be done. Question Jaundice in the newborn is common. Why? Jaundice in the newborn is called Neonatal Jaundice. It is common because before birth, an infant get rid of bilirubin through the mothers blood and liver system. After birth, the babys liver has to take over processing on its own. The activity of the hepatic conjugation enzyme is usually low at birth but increases rapidly thereafter. Almost all newborns have higher than normal level of bilirubin; because the immaturity of their livers. In most cases, the babys system continues to develop and can soon process bilirubin. However, some infants may need medical treatment to prevent serious complications which can occur due to the accumulation of bilirubin. There are at least two significant processes that predispose normal infants to jaundice: The rate of bilirubin production is higher in infants than adults because their red blood cells have half-life and turn over more rapidly. Infants have a relatively limited ability to conjugate bilirubin and conjugation in the liver is necessary for efficient elimination. Write short notes on Gilberts disease. Gilberts disease is a harmless inherited condition in which the unconjugated bilirubin level in the blood is increased. Bilirubin is an end product of haemoglobin breakdown and it is conjugated in the liver with glucuronate. This process is catalysed by specific enzyme called uidine diophosphate glucuronyl transferase which is found in endoplasmic reticulum, which helps the body to conjugate bilirubin and get rid of it. Thus Gilberts syndrome is a genetic disorder which means that there is slight deficiency of this enzyme. Patient with Gilberts disease can have intermittent bilirubin level but the values are often increased when blood is drown after a period of fasting or during a time of concurrent viral illness or when the person is stressed, either physically or mentally. People with Gilberts syndrome are not ill but they may complain of vague abdominal discomfort and general fatigue for which no cause found. The condition is not usua lly apparent until adolescence or early adult life. It is sometimes discovered incidentally, in the course of investigations done for related reasons. All liver function tests (LFTs) are normal, except for serum bilirubin which is raised. X-ray and liver biopsy show that there is no liver disease. Gilberts syndrome should not be regarded as a disease and people with the syndrome are not ill.

The Creation of Tension and Suspense in Othello by William...

The Creation of Tension and Suspense in Othello by William Shakespeare â€Å"Killing myself, to die upon a kiss†. These are Othello’s last words, as he commits suicide and dies next to his wife. After ironically killing her himself at the end of Act 5. Othello was written in 1608 a time when the Ottoman Empire was at war with the Venetians. Othello is a tragedy because of the deception and betrayal of Iago which causes many people to die. The play explores many different themes each trying to convey a specific message. The main themes of the play are betrayal, revenge, love, trust, honesty, racism and social hierarchy. These are only some of the themes explored in the play. White men were seen as†¦show more content†¦We find out that Rodrigo is in love with Desdemona, and Iago is angry with Othello for making Cassio his lieutenant instead of him and wants revenge. Brabantio is told of Desdemona and Othello’s marriage and goes looking for her. Brabantio accuses Othello of abducting his daughter Brabantio takes the matter to the duke. Desdemona confirms that she is in love with Othello and requests she go with him to war. Iago reassures Rodrigo that he is going to get Desdemona back as he is in love with her. We find out In Iago’s last speech (soliloquy) what his plans are and part of the reason why he hates Othello so much. We find out that the war is over and the Venetians have won. Iago cruelly convinces Rodrigo that Cassio and Desdemona are falling for each other. Iago talks with Cassio about Desdemona, and Iago being very crude about her, saying that she is provocative. Rodrigo and Cassio fight. Iago sows suspicions in Othel lo’s mind until he is convinced that Desdemona is false to him. Emilia gives Othello’s handkerchief to her husband. This is very important in making Iago’s manipulative scheme work. Iago uses the handkerchief as proof for Othello that his wife is cheating on him by giving the handkerchief to Cassio. Iago continues to provoke Othello’s jealousy. Until he is convinced that Desdemona has been deceitful. Lodvico is horrified when he sees OthelloShow MoreRelatedInsight to Coach Carter Film7710 Words   |  31 PagesCOACH CARTER Production Information Tension mounted as the Richmond High Oilers faced the upcoming basketball championship. The town was wild with excitement over their undefeated team and the bleachers were filled with cheering fans for every game. No one could imagine that on January 4, 1999 the community would erupt in dissention and so many lives would change forever when Coach Ken Carter padlocked the gym, refusing the players access for failing to keep up their grades. Inspired by a true

Pancasila Free Essays

string(167) " of the judge come out, the mass on the court altogether destroy the buildings \(three churches and one Catholic school\), break the glass and other facilities there\." CHAPTER I BACKGROUND Indonesia is a country which has a strong philosophy to control the whole system of the country. In its preamble, the 1945 constitution sets forth the Pancasila as the embodiment of basic principles of an independent Indonesian state. These five principles were announced by Sukarno in a speech known as â€Å"The Birth of the Pancasila,† which he gave to the Independence Preparatory Committee on June 1, 1945. We will write a custom essay sample on Pancasila or any similar topic only for you Order Now In brief, and in the order given in the constitution, the Pancasila principles are: belief in one supreme God; humanitarianism; nationalism expressed in the unity of Indonesia; consultative democracy; and social justice. Sukarno’s statement of the Pancasila, while simple in form, resulted from a complex and sophisticated appreciation of the ideological needs of the new nation. The details about each principles: 1. Belief in the one and only God The symbol of this principle is star. This principle tells us about belief in God. It shows that the Indonesian people believe in life after death. It emphasizes that the pursuit of sacred values will lead the people to a better life in the hereafter. The principle is embodied in the 1945 Constitution and reads: â€Å"The state shall be based on the belief in the one and only God†. It is represented by the star in the centre of the shield of the Garuda Pancasila. 2. Just and civilized humanity The symbol of this principle is chain. This principle requires that human beings be treated with due regard to their dignity as God’s creatures. It emphasizes that the Indonesian people do not tolerate physical or spiritual oppression of human beings by their own people or by any other nation. The chain at the lower right of the shield symbolizes successive generations of humanity. 3. The unity of Indonesia The symbol of this principle is banyan tree. This principle talks about the concept of nationalism, of love for one’s nation and motherland. Pancasila nationalism demands that Indonesians avoid feelings of superiority on the grounds of ethnicity, for reasons of ancestry and skin color. In his 1 June 1945 speech, Sukarno quoted Gandhi: I am a nationalist, but my nationalism is humanity. The Indonesian coat of arms enshrines the symbol of â€Å"Bhinneka Tunggal Ika† which means â€Å"unity in diversity†. This is represented on the shield by the banyan tree at top right. 4. Democracy guided by the inner wisdom in the unanimity arising out of deliberations amongst representatives The symbol of this principle is the buffalo’s head. Pancasila democracy calls for decision-making through deliberations to reach a consensus. It implies that voting is not encouraged as long as deliberation is possible. It is democracy that lives up to the principles of Pancasila. The head of the wild bull at top left stands for this principle. 5. Social justice for the whole of the people of Indonesia The symbol of this principle is the rice and cotton. This principle calls for the equitable spread of welfare to the entire population, not in a static but in a dynamic and progressive way. This means that all of the country’s natural resources and the national potentials should be utilized for the greatest possible good and happiness of the people. Social justice implies protection of the weak. But protection should not deny them work. On the contrary, they should work according to their abilities and fields of activity. Protection should prevent wilful treatment by the strong and ensure the rule of justice. This is symbolized by the paddy and cotton ears on the shield. Those principle are the base of Indonesia. All the constitution, rule, regulation, law, and system in this country must follow those principles. All activities related with Indonesia cannot be contrarily with its state philosophy. This state philosophy also can help the government to solve some problems in the country. That is why Pancasila is made and conclude all aspects that are needed in country’s life. CHAPTER II VIOLATION OF PANCASILA 2. 1 The Issue Religious violence is not talking about good violence or the type of violence which is allowed by the religion. It talks about the violence action that bring such name of religion to attack other belief or religion. The head of Setara Institute for Democracy and Peace, Hendardi stated that within the last three years, the violence that bring the name of religion happened frequently, even more frequent than before. From the beginning of 2010, 27th of April, thousands of people attacked â€Å"Yayasan Badan Pendidikan Kristen† (BPK) complex at Cisarua, Bogor. Not less than six buildings was burnt. Then, on 1st of October, a thousand people invaded Ahmadiyah area at Cisalada, Ciampea, Bogor and broke six buildings. On 12th of September in the same year, Christian community of HKBP Pondok Timur Indah Church was attacked when they were going to do the service. A preacher was also being stabbed by the attacker. The violence was not ended at 2010, entering 2011, on 6th of February, a thousand of people attacked Ahmadiyah Cikeusik, Pandeglang. Three Ahmadiyah people was died in this incident. Two days after that there were some people broke and burnt three churches and one Catholic school at Temanggung, Central Java. Those violence causes death of some people and a big losses for some parties. That religious violence is easily published by the media. Even in one media, there is one Indonesian who live in Cairo, Egypt, state his cynical thought, â€Å"That is Indonesia which is never reach maturity stage. Other countries are trying to get out from the cage of primordialism but we still stay the same. † It shows that religious violence in Indonesia is also heard by other countries or even by the whole world. One case that recently happened is the case on Temanggung, Central Java. That chaos happened after the judge verdicts 5-year punishment in jail to Antonius Richmon Bawengan who is judged as a person who insult other religion. Right after the decision of the judge come out, the mass on the court altogether destroy the buildings (three churches and one Catholic school), break the glass and other facilities there. You read "Pancasila" in category "Essay examples" Those violence has caused great chaotic in Temanggung. Some roads must be closed due to the barbaric action of the mass. It also causes great loss to some parties. The reason for that religious violence is mass’ disappointment because of the judge decision. They think the punishment is too small for the person who insults religion. Actually, there is another happening before that religious violence happens. On 3rd of October 2010, Antonius Richmon stayed at his relative’s house in Kenalan village, Temanggung, Central Java. On that day, Antonius spread some books, that contain some statement that were considered as humiliation for the Moslem, to the Moslem mass around him. That is why the mass in that village were disturbed by his action and decided to arrest him since 26th of October 2010. The oddity in this case is most of the mass that was doing the violence were coming from outside Temanggung. The secretary of â€Å"Forum Kerukunan Umat Beragama† (The Harmony of Religion), Djundardo, said â€Å"Most of the mass that do the violence was coming from outside Temanggung because, basicaly, Temanggung has good harmony in inter-religion interactions. † 2. 2 Analysis based on principles of Pancasila This case has violated several principle of Pancasila which must be our base in everything people do in this country. For the most, it totally violates the first principle â€Å"Belief in the one and only God†. This principle does not mean that all of Indonesian must have one religion. Indonesia acknowledges five religions before and six religions for now. It means that this principle encourage the entire citizen to respect other religion and belief. It says one and only God to emphasize that we have one goal, one destination, and one same point at the last so the one that makes each religion different is the way to reach that goals. The former of Pancasila already thought about it carefully. They just wanted all citizens can have good harmony just like a big family, even though there is diverse religion and belief in it. Unfortunately, the fact, nowadays, is really contrast with the Pancasila’s former expectation. If we see the â€Å"religious violence†, it shows that there is lack of respect to other religion. They tend to defend their own religion by violence. They think that their religion is the best and because of that they lose the harmony of inter-religion relationship which is expected by the former from the first principle. The people who do violence forget about the first principle that said about the one and only God which means unity in one God. The principle means the last destination of each religion is one and only God who loves all people who believe on Him, so people do not have any right to judge which religion is the best among others. Besides that, none of the religion that tells people to solve problems with violence actions. If there is some people who do violence action and bring the name of religion, it means those people are not respect their own religion and God. That is why, this violence which attack other religion has considered as violation the first principle of Pancasila. Besides that, religious violence also violates second principle of Pancasila â€Å"Just and civilized humanity† because it harm so many people’s life. Civilized humanity describes the society that can treat the people who live there fairly, are polite and behave in a calm and reasonable way. The violence is a contrast action of civilized humanity. It shows that the mass, that kill other people, break others’ properties, and even obstruct others’ religion, imply impoliteness and barbarian behavior. It totally do not implement the second principle of Pancasila. Those actions also violate the third principle of Pancasila â€Å"The unity of Indonesia† because those actions can trigger any disunity among the citizen of Indonesia. Basically, unity never means all people must in the same thought, same condition, or same choice. Unity can be reached when we can respect others thought, condition and choice to reach one goal; also when we can harmonize that diversity and, the most important, has the sense of belonging to all of the member. In this religious violence, we cannot see the sense of belonging of those people or even their effort to respect others’ belief. They try to attack others because they think that religion is not appropriate to exist and be believed there. At the last, religious violence can be counted as violation of the fifth principle â€Å"Social justice for the whole of the people of Indonesia†. It violates this principle due to the closing of some churches which is unfair for the Christians who live kindly and nicely to the society. In this principle, the former said â€Å"for the whole of people of Indonesia† not for several people which means there must be no discrimination to get social justice. People should not judge a religion based on one-man action which does not describe the characteristic the whole of people who taking up that religion. 2. 3 Solutions Government need to remember and understand deeply about our Constitution. We must realize that we are in the democratic country, not an authoritative one. It means that we must respect others’ thought and belief; we cannot force others to have the same thought and belief with us. If we can realize it, hopefully, our country can be calmer and has harmonious inter-religion life. Government also needs to be strict in law to cope this issue. It is not only in law but also in its implementation. If someone harms others’ life, especially with harassment, it must be considered as a crime and he/ she must be arrested based on the law. Government need to repair their mind to do their work to serve the whole citizen wholehearted and fairly. Besides all of that, we also can start to resolve the issue by ourselves. We must learn to respect others’ belief and not judge a society by one-man action only. We must try to open our mind to the diversity around us and share our knowledge to the people who still lack of this awareness. We also need to socialize with all people in our society, not only people who have same belief or interest with us. CHAPTER III CONCLUSION Indonesia is a country which established with a strong state philosophy which is called Pancasila. Pancasila consists of five basic principles which already covers all aspects in country’s life. The principles include the belief, humanity, unity, democracy, and justice. Those principles are called as state philosophy because those five principles are the fundamental principle to run the country. It means every single thing which is done in and for the country must agree with Pancasila. On the other hand, if we see the reality nowadays, there is some violation in regards of Pancasila. One kind of the violation is religious violence, which means some violence action which brings a name of religion. This issue becomes more frequent lately. The last case is in Temanggung where there are three churches and a Catholic school were destroyed by the mass which bring the name of Islam. That violence had caused chaotic and terrified situation in Temanggung because the mass was looked so brutal. This case has totally broke the first principle of Pancasila which said belief in one and only God. 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